Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus
نویسندگان
چکیده
منابع مشابه
Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus
Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...
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β-lactam antibiotics are among the most popular classes of antibacterial agents, whose mechanism of action consists on the inhibition of bacterial cell wall synthesis.1 The production of β-lactamase is the most important mechanism for bacterial resistance to β-lactam antibiotics.2 Secondary metabolites produced by bacteria exhibit potent biological activities and have been developed extensively...
متن کاملOverproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus
Clavulanic acid is produced industrially by fermentation of Streptomyces clavuligerus and researches have increased its production by strain improvement, recombinant DNA technology, and media composition and growth condition optimization. The main objective of this study was to increase the level of clavulanic acid production from Streptomyces clavuligerus (DSM 738), using UV irradiation. After...
متن کاملProduction of Clavulanic Acid by Streptomyces clavuligerus in Batch Cultures with Using Wheat Bran as the Source of Carbon
Nowadays Microbial biotechnology is considered as one of the most important and profitable branches of industry. In this approach, by using the generator microorganisms, We are able to produce biotechnological products, with higher efficiency. Clavulanic acid is being used in combination with commonly used beta-lactam antibiotics in order to fight against bacterial infections that are resistant...
متن کاملEffect of single additive bivalent metal ions on the growth of Streptomyces clavuligerus and clavulanic acid production
Metal ions are the main impurities of water and media ingredients used in fermentation processes. In this research, the effect of Ca+2, Co+2, Cu+2, Fe+2, Mg+2, Mn+2 and Zn+2 as chloride and sulfate salts was studied on the clavulanic acid production and Streptomyces clavuligerus growth. All chloride salts had negative effect on clavulanic acid production and no clavulanic acid was produced in t...
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ژورنال
عنوان ژورنال: Microbiology
سال: 1997
ISSN: 1350-0872,1465-2080
DOI: 10.1099/00221287-143-11-3573